APL is an abbreviation, acronym, or initialism that may refer to:
- Above Poverty Line, the section of people who can fulfil their minimum basic needs
- Acute promyelocytic leukemia, a subtype of acute myelogenous leukemia
- Acting Patrol Leader
- Alliance pour le Progrès et la Liberté
- apl.de.ap, pseudonym of Allan Pineda Lindo, a member of hip hop group The Black Eyed Peas
- AMD Performance Library, a compiler library for AMD multi-threaded processors
- American President Lines, a Singapore-based container transportation and shipping company
- American Protective League, a WWI era pro-war organization
- apl, file extension of the Monkey's Audio metadata file
- APL, United States Navy hull classification symbol for Barracks Craft
- Applied Physics Letters, journal published by American Institute of Physics
- Applied Physics Laboratory, Johns Hopkins University
- Assistant Patrol Leader
- Association of Pension Lawyers
- Australian Poker League, offers free poker in pubs and clubs
- Australian Premier League, an online football gaming league
- Average Picture Level, a Federal Standard 1037C term
- Nampula Airport, Mozambique, from its IATA airport code
- several software licenses, including:
- Irish Anti-Partition League
- Albanian Party of Labour
Furthermore, APL is the name of an asteroid: 132524 APL
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